COMT and metabolic dysfunction-associated steatotic liver disease: In addition, it is important to note that Vitamin E is protective for non-alcoholic fatty liver disease [52]; therefore our data also suggest that subjects with AO should increase their vitamin E intake levels to help with this problem, although this is more important for those with the rs2301241 (TXN) TT or the rs740603 (COMT) GG genotype.