In all melanoma samples the mean overall 5-year survival in the low LIFr expression group was 75.6% compared to 39.6% in the high LIFr expression group; a significant difference by log-rank analysis (overall survival, P = 0.0000; disease-specific survival, P = 0.0000, log-rank test) (Figure 3). This evidence concerns the gene LIFR and melanoma.