Among the groups, no normal nevi showed strong LIFr expression, LIFr staining was significantly more common in primary melanoma, with a subset exhibiting strong staining, compared to dysplastic nevi (P = 0.0003, χ2 test), and expression was further increased in metastatic melanoma (P = 0.0000, χ2 test) (Figure 1). This evidence concerns the gene LIFR and metastatic melanoma.