Moreover, a significant attenuation in either TNF-α (Fig. 2E) or IL-6 (Fig. 2F) release was observed in hMrp8 pre-stimulated human monocytes after re-stimulation with heat-killed S. typhimurium or S. aureus (p < 0.05 and p < 0.01 versus naive cells), demonstrating that similar to mMrp8, hMrp8 pre-stimulation induces cross-tolerance to bacterial infection in human monocytes also. The gene discussed is TNF; the disease is bacterial infectious disease.