Recently, Kornfeld and colleagues found that obesity-induced overexpression of miR-802 causes glucose intolerance, impairs insulin signaling, and promotes hepatic gluconeogenesis in the liver through direct silencing of HNF1B, and showed an important role for HNF1B in the control of hepatic insulin sensitivity and glucose metabolism in vivo [39]. The gene discussed is INS; the disease is Glucose intolerance.