Recently, Kornfeld and colleagues found that obesity-induced overexpression of miR-802 causes glucose intolerance, impairs insulin signaling, and promotes hepatic gluconeogenesis in the liver through direct silencing of HNF1B, and showed an important role for HNF1B in the control of hepatic insulin sensitivity and glucose metabolism in vivo [39]. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.