One 3′UTR SNP (rs2229295) in the HNF1B gene was significantly associated with T2DM, and the frequency of CA and AA genotypes of rs2229295 in T2DM patients was decreased compared with that in controls (OR = 0.66 (95 % CI: 0.50–0.88), 0.44 (95 % CI: 0.25–0.77), respectively)) (Table 2). This evidence concerns the gene HNF1B and type 2 diabetes mellitus.