Because the activity of telomerase is modulated by POT1 and because the recruitment of hPOT1 to the single-stranded telomeric DNA is hampered by the formation of G-quadruplex structure at the single-stranded nucleotides, it is reasonable to hypothesize that the inducer or stabilizer of G-quadruplex complexes can be a promising candidate for therapeutics for cancer. This evidence concerns the gene POT1 and cancer.