Moreover, most of the work identifying the effect of Cav-1 expression on PCa aggressiveness and angiogenic potential [18, 21, 23, 30, 31] precedes the recognition that in the absence of PTRF, cells cannot form caveolae and Cav-1 resides in a different compartment [32] and therefore did not differentiate between the effects of caveolar Cav-1 and non-caveolar Cav-1, which we are now able to dissect out [11, 33-35]. The gene discussed is CAV1; the disease is posterior cortical atrophy.