HDAC6 and Miyoshi myopathy: Indeed, other groups have investigated the role of autophagy during proteasome inhibition (Kawaguchi et al., 2011; Santo et al., 2012; Komatsu et al., 2013; Moriya et al., 2013; Mishima et al., 2015), and combinations of bortezomib with autophagy inhibitors, including hydroxychloroquine (Vogl et al., 2014) and the HDAC6 inhibitor ACY-1215 (ClinicalTrail.gov identifier NCT01323751), are currently in clinical trials for MM.