Moreover, to determine the contribution of SIRT1 activity in the pathophysiology of early stress-associated depression, the ‘developmental dynamics' of ESI-induced changes in SIRT1 expression throughout life in mice must be followed, and SIRT1-dependent alterations in biological mechanisms during ESI should be identified, guiding the identification of pharmacological targets for preventive and therapeutic interventions. This evidence concerns the gene SIRT1 and depressive disorder.