MYC and neoplasm: To formally test the hypothesis that Myc and KSHV latent genes cooperate to induce lymphoid hyperplasia and neoplasia, Myc transgenic (n = 42), the KSHV latency locus transgenic (n = 41), and Myc/KSHV latency locus double transgenic mice (n = 40) were monitored for 500 days (Fig 4A and 4B).