Transgenic mice expressing a translocated Myc gene from a human BL cell line under the Igλ light chain regulatory sequences also readily developed lymphomas [8], whereas transgenic mice with a specific, single copy targeted insertion into the Cα of the IgH locus (iMycCα mouse), which mimic the t(8;14) in BL, developed B cell lymphomas with very low incidence [7]. This evidence concerns the gene MYC and Burkitt lymphoma.