To bolster our findings that HRGβ2 and RAP1 form a protein complex in vivo, we next performed indirect immunofluorescent studies and co-immunoprecipitation assays in MDA-MB-231 and Hs578T BC cells, two metastatic cancer cell models that naturally overexpress HRGβ2 [16]. The gene discussed is TERF2IP; the disease is cancer.