Following adjustment for age, BMI, smoking, alcohol, refraction, CKD, IHD, CVA and diabetes mellitus (Model 2), and medications used at a frequency >5% within the cohort (ACE inhibitors, aspirin, beta blockers, calcium channel blockers, corticosteroids, diuretics, NSAIDs and statins [Model 3]) and fellow vessel (Model 4), hypertension status remained significantly associated with arteriolar vessel caliber (Table 3: P = 0.002; effect size = -2.16 μm; CI: -3.51, -0.81). This evidence concerns the gene ACE and Hypertension.