PKD1 and Renal cyst: It is characterized by the development of bilateral renal cysts frequently caused by mutations in proteins PKD1 and PKD2 encoding polycystins 1 and 2 [1].Genetic analyses carried out in the laboratory in the PKD/Mhm(cy/+) rat model of ADPKD revealed that the disease spontaneously develops as a consequence of a mutation (R823W) in the Sterile Alpha Motif (SAM) domain of Ankyrin repeat and sterile alpha motif domain containing 6 (Anks6) [2].