Our results in mice also suggest that impaired osmoregulation caused by stimulation of the vasopressin and vasopressin V2 receptor systems, which are involved in cystogenesis and have led to new therapeutic developments in ADPKD [28], may at least partly account for PKD caused by Anks6 mutation preventing ANKS6-ANKS3 interactions. The gene discussed is ANKS3; the disease is autosomal dominant polycystic kidney disease.