ANKS6 and cystic kidney disease: Most recently, we reported spontaneous development of renal cysts in mice carrying a N-ethyl-N-nitrosourea (ENU)-induced missense mutation (I747N) located only six amino acids away from the R823W mutation in cy/+ rats, which further supports the crucial role of the SAM domain of ANKS6 in cystogenesis in mammalian species [7].