Appreciating previous observations with regard to NCAM and FGFR1 interplay and their functional significance in the activation and proliferation of fibroblasts [6–9], it might be that detection of abundant NCAM/FGFR1 overlapping in some cases of incipient IRF can suggest possible progression to advanced stages of renal fibrosis, and it is tempting to speculate that inhibition of NCAM/FGFR1 interaction can ameliorate renal fibrosis which remains to be clarified in the future. The gene discussed is FGFR1; the disease is renal fibrosis.