The third signal is captured by a common variant rs17248720-T (NM_000527.4:c.-2038C>T, MAF = 8.8%) located at the 5’ end of LDLR that lowers non-HDL-C by 0.24 mmol/l (Padj = 1.8× 10−80) and has been reported to lower LDL-C levels with similar effect as shown here and confer protection against CAD [9,20]. The gene discussed is LDLR; the disease is coronary artery disorder.