The LDL receptor and its role in LDL-C regulation was discovered 40 years ago when Goldstein and Brown set out to unravel the cause of familial hypercholesterolemia (FH) [5], a severe autosomal dominant disorder characterized by high levels of LDL-C in blood and premature cardiovascular disease [6]. The gene discussed is LDLR; the disease is familial hyperaldosteronism.