PRDX6 and myeloid sarcoma: In conclusion, our findings strongly support that upregulation of astrocytic PRDX6 has an important role in orchestrating myelin destruction via microglial activation, BBB breakdown, and immune cell infiltration, resulting in demyelination and axonal loss in MS, as well as our data provide the concept that PRDX6 gives rise to great potential in prevention and treatment of MS.