CD30, a tumor necrosis factor (TNF) receptor targeted by Brentuximab, is highly expressed on Hodgkin's lymphomas and systemic anaplastic large-cell lymphomas; although this target's expression is restricted to the immune system, CD30 is also present on normal activated T, B, NK cells, and monocytes [34]. The gene discussed is TNFRSF8; the disease is Hodgkins lymphoma.