For example, fibroblast migration was shown to be regulated by endocytosis of platelet-derived growth factor (PDGF) receptor [39], and chemotactic invasion of MDA-MB-231 breast cancer cells and pancreatic ductal adenocarcinoma cells by clathrin-mediated endocytosis of epidermal growth factor (EGF) receptor [40]. This evidence concerns the gene EGF and pancreatic ductal adenocarcinoma.