EGFR-mutated tumors depend on EGFR signaling for their proliferation and survival: consistently, the EGFR tyrosine kinase inhibitors (TKIs) gefitinib, erlotinib and afatinib represent a relevant therapeutic option for NSCLC patients with EGFR activating mutations [5–7]. Here, EGFR is linked to non-small cell lung carcinoma.