Others have found that targeting EGFR by using two different classes of inhibitors, namely a monoclonal antibody directed against the extracellular portion of the receptor and a TKI able to interfere with ATP binding, is effective in in vitro models of NSCLC harboring the T790M mutation; together, these agents efficiently depleted both phosphorylated and total EGFR [24]. Here, EGFR is linked to non-small cell lung carcinoma.