Most importantly, other programs with potential pathogenetic significance were enriched in EBV-positive BL, including some that are also mediated by known oncogenes such as KRAS, ALK, CCND1, and JNK, and programs related with signal transduction of G protein-coupled receptors (GPCR) (Supplementary Table 3). The gene discussed is MAPK8; the disease is Burkitt lymphoma.