Further, to make our data more robust, the differential expression of PLCD4, METTL6, CIDEB and CRLF3 was tested and validated in an independent, previously described set of cases, including 13 EBV-positive BL and 20 EBV-negative BL cases [5](Supplementary Figure 1). This evidence concerns the gene CRLF3 and Burkitt lymphoma.