TMEM88 and invasive ductal breast carcinoma: In contrast, TMEM88 was moderately expressed in carcinomas in situ and highly expressed in invasive ductal carcinomas (IDCs) (Figure 1B and 1C); however, the rate of positive expression was significantly higher in IDCs (71.22%, 99/139) than in normal breast ductal epithelium (11.4%, 4/35; p < 0.001; Figure 1D).