DVL1 and triple-negative breast carcinoma: While TMEM88 exhibited cytoplasmic localization in each of the cell lines tested (Figure 2A), the expression level of the 17-kDa TMEM88 isoform, which interacts with Dvl proteins, was significantly higher in the triple-negative breast cancer cell lines (MDA-MB-231 and MDA-MB-468) than in the normal breast cells (Figure 2B).