TMEM88 and triple-negative breast carcinoma: In both the overall breast cancer specimens and the triple-negative breast cancer specimens, cytosolic TMEM88 localization correlated positively with both lymph node metastasis (p = 0.01 and p = 0.002, respectively) and tumor node metastasis (TNM) stage (p = 0.038 and p < 0.001, respectively; Table 2).