However, there was no difference in the normalized levels of the 25-kDa TMEM88 isoform, which lacked the VWV sequence (Dvl-binding motif), in breast cancer tissues(mean ± SD: 0.506 ± 0.388) relative to the paired noncancerous tissues (mean ± SD: 0.457 ± 0.314; p = 0.472; Figure 1G and 1H). The gene discussed is TMEM88; the disease is breast cancer.