This contrasts the findings of a recent cross-sectional study in GDM where betatrophin was positively associated with FPG and HOMA-IR but inversely correlated with HOMA-β.[22] In the regression analysis we find that C-peptide-peptide levels are negatively related to betatrophin which is concordant with findings of Tokumoto et al. in non-pregnant subjects [22, 23] However in our study HOMA-ß did not correlate with betatrophin, but this calculated parameter is indeed not the most suitable parameter for evaluation of beta cell function. The gene discussed is ANGPTL8; the disease is gestational diabetes.