In contrast to two recent studies, that investigated the relationship between betatrophin and lipids, we found that betatrophin correlated with circulating lipid parameters such as triglycerides, total cholesterol, but not HDL cholesterol, in NGT and GDM women together, which is in accordance with our own previous findings in obesity and type 2 diabetes and other studies.[10, 28] Indeed betatrophin has been implicated in triglyceride regulation by mechanisms involving altered hepatic very low density lipoprotein secretion and lipoprotein lipase activity. This evidence concerns the gene ANGPTL8 and obesity due to melanocortin 4 receptor deficiency.