In GDM the combination of enhanced insulin resistance, impaired insulin release, and pregnancy-related hormonal changes contribute to an unfavorable dyslipidemic state.[16] Also a positive correlation between maternal triglycerides (TG) and neonatal body weight has been detected.[17] Overall these findings suggest that altered maternal lipid metabolism rather than hyperglycaemia constitutes a risk for diabetic fetopathy and macrosomia in GDM.[18] Release and regulation of betatrophin in women with GDM as well as its association with glucose and lipid metabolism have not been elucidated yet. This evidence concerns the gene INS and Insulin resistance.