ANGPTL8 and Insulin resistance: In GDM the combination of enhanced insulin resistance, impaired insulin release, and pregnancy-related hormonal changes contribute to an unfavorable dyslipidemic state.[16] Also a positive correlation between maternal triglycerides (TG) and neonatal body weight has been detected.[17] Overall these findings suggest that altered maternal lipid metabolism rather than hyperglycaemia constitutes a risk for diabetic fetopathy and macrosomia in GDM.[18] Release and regulation of betatrophin in women with GDM as well as its association with glucose and lipid metabolism have not been elucidated yet.