ALB and brain edema: High-dose human albumin was shown in pre-clinical rodent stroke models to be a highly neuroprotective agent.[1, 2] Albumin reduces infarction volume and cerebral edema, and improves behavioral function, with a therapeutic window of efficacy of at least 4 hours after stroke onset.[1, 3] Albumin normalizes the apparent diffusion coefficient within the residual infarct, relieves obstructions in postischemic cortical venules[4], and improves microvascular hemodynamics distal to an arterial thrombosis.[5–7]