Among the predicted miRNA-mRNA interactions, the regulatory pair miR-34a—AXL has been implicated in chronic lymphocytic leukemia, breast cancer and other cancer types [58–60]; miR-200b and miR-200c were proven as major regulators of EP300, which suppresses metastasis in ductal adenocarcinomas of the pancreas [61]. The gene discussed is EP300; the disease is B-cell chronic lymphocytic leukemia.