CCC729 showed reduction in expression in the cells for ten cancer marker proteins: soluble human epidermal growth factor receptor 2 (sHER-2/neu), follistatin, granulocyte colony stimulating factor (G-CSF), prolactin, soluble epidermal growth factor receptor (sEGFR), soluble Tie2 receptor (sTIE-2), soluble vascular endothelial growth factor receptor 1 (sVEGFR-1), and platelet derived growth factor, a dimeric glycoprotein composed of two A (-AA) or two B (-BB) chains (PDGF-AB/BB; Fig 8A), as well as osteopontin (Fig 8B) and hepatocyte growth factor (HGF; Fig 8C). The gene discussed is SPP1; the disease is cancer.