In this study, we show for the first time that miR-206 directly targets and regulates the full-length 3′-UTR of the human BCL2 (B-cell lymphoma-2) gene, and confirmed that miR-206 directly targets and regulates the full-length 3′-UTR of the human MET mRNA, which are up-regulated in many cancers, including lung cancer. This evidence concerns the gene BCL2 and lung cancer.