Thus, we next examined c-Met, Bcl2 and cyclin D1 expression in human primary lung tumors (NSCLS) and pair-matched lung tissues, and our western blot results demonstrated that the expression of c-Met, Bcl2 and cyclin D1 proteins were all increased in lung cancer tissues compared with normal lung tissues (Fig. 2A, 2C and 2E). The gene discussed is CCND1; the disease is lung cancer.