Moreover, the luciferase assay using a reporter containing the wild type miR-206 binding sequence at the 3′-UTR of c-Met and Bcl2 mRNA indicated that the luciferase activity could be significantly reduced or increased by over-expression or down-regulation of miR-206, which was in accordance with Yan's investigation that miR-206 targeted MET in Rhabdomyosarcoma. Here, BCL2 is linked to rhabdomyosarcoma.