In agreement with a recent study that demonstrated c-Rel is required for the GC maintenance [17], our data showed distinctive c-Rel signatures in GCB- DLBCL but not in the overall ABC-DLBCL cohort (Fig. 3J); BCL6, essential for GC maintenance, was upregulated in both c-Rel+/Bcl-2− and c-Rel+/p63− DLBCL (Fig. 3K-3L). This evidence concerns the gene BCL6 and aneurysmal bone cyst.