Upregulation of TNFAIP3/A20 and TNIP1 (which inhibit MALT1, IKK3 and TRAF6 [37]) in c-Rel+ GCB-DLBCL (Fig. 3E) may be relevant for the decrease of pAKT and Myc levels coincided with c-Rel positivity (Fig. 3A-3C) and the lack of c-Rel prognostic impact [39, 40]. Here, REL is linked to diffuse large B-cell lymphoma.