In p63− DLBCL, c-Rel expression was associated with upregulation of BCL6, EGR1, AEBP1, C7orf68, CCNG2, CCNI, ILKAP, and PSMG4 (encoding a chaperone protein which promotes assembly of the 20S proteasome) and downregulation of FBXO22 (involved in degradation of specific proteins in response to p53 induction) (Fig. 3L). This evidence concerns the gene TP53 and diffuse large B-cell lymphoma.