Using this cutoff, 137 patients (26.3%) of the 460 successfully stained cases had c-Rel+ DLBCL, with different expression levels (5–90% of the tumor cells with c-Rel+ nuclei), whereas majority (73.7%) of the cases were negative for c-Rel nuclear expression with or without cytoplasmic staining (Fig. 1B, Supplementary Fig. S1A). Here, REL is linked to neoplasm.