Compared with studies in the literature, the positivity frequency in our study is lower than the 65% and 64% by two previous reports (0% and 30% cutoff respectively) [34, 35], and higher than the 18% by another study using a >50% cutoff [54]; the prognostic significance of c-Rel nuclear expression in MUT-p53 and various ABC-DLBCL subsets demonstrated in our cohort have not been reported previously. This evidence concerns the gene REL and diffuse large B-cell lymphoma.