Our data suggested crosstalk exist between c-Rel and the p53 pathway, including MUT-TP53 induction at the transcriptional level in c-Rel+ ABC-DLBCL, the gain or loss of correlation with expression levels of genes involved in cell cycle (p21, AURKB), apoptosis (BIRC5, BCL2L11), TNF pathways (TRAF2, TANK), and tumor suppressor TP63. Concurrent c-Rel positivity and TP53 mutation correlated with significantly worse patient survival. Here, REL is linked to diffuse large B-cell lymphoma.