To understand the tumor suppressor function of p63 towards c-Rel signaling, we further compared GEP between p63+ and p63− patients within the c-Rel+ DLBCL subset, and found that LYN was significantly downregulated in p63+ DLBCL, suggesting that p63 may inhibit BCR signaling thus attenuate c-Rel activation. This evidence concerns the gene REL and diffuse large B-cell lymphoma.