These correlations may not have resulted from transcriptional regulations by c-Rel, since c-Rel positivity did not correlate with AKT1, MYC (Supplementary Fig. S1I-1J) or TP53 (P = 0.34 in GCB-DLBCL, and P = 0.088 for TP53 upregulation in ABC-DLBCL) mRNA expression significantly, and that in GCB-DLBCL cases without MYC translocations, c-Rel+ still correlated with decreased Myc levels in GCB-DLBCL. This evidence concerns the gene REL and diffuse large B-cell lymphoma.