Our data also suggested possible lost-of-function of c-Rel in the presence of MUT-p53 in upregulating TP63 in ABC-DLBCL, and gain-of-function in inducing NFKB1, TANK, and BCL2L11 in GCB-DLBCL, AURKB, RELA, and BAD in ABC-DLBCL, as well as downregulating TRAF2 in GCB-DLBCL and BCL2L11 in ABC-DLBCL (Supplementary Fig. S5–S6). The gene discussed is REL; the disease is diffuse large B-cell lymphoma.