In p63− DLBCL, c-Rel expression was associated with upregulation of BCL6, EGR1, AEBP1, C7orf68, CCNG2, CCNI, ILKAP, and PSMG4 (encoding a chaperone protein which promotes assembly of the 20S proteasome) and downregulation of FBXO22 (involved in degradation of specific proteins in response to p53 induction) (Fig. 3L). Here, FBXO22 is linked to diffuse large B-cell lymphoma.