Dividing into GCB and ABC subcohorts, the P values for the prognostic significance of c-Rel positivity remained significant for OS in both GCB- and ABC-DLBCL with WT-p53 after adjusting all the clinical parameters (P = 0.025 and P = 0.019 respectively), and for PFS in ABC-DLBCL with WT-p53 (P = 0.04). This evidence concerns the gene REL and diffuse large B-cell lymphoma.