We analyzed expression of c-Rel and p53 target genes, which appeared to suggest that MUT-p53 and c-Rel gained functions in downregulating p21 in GCB-DLBCL (Fig. 4E-4F), and upregulating BIRC5 (encoding antiapoptotic survivin) in ABC-DLBCL (Fig. 4G-4H). The gene discussed is REL; the disease is diffuse large B-cell lymphoma.