Upregulation of FOXP3 [42], FOXO3 [46], A20 [39, 40], IKK2 and IκBs [41, 49] in c-Rel+ GCB-DLBCL may be relevant for the reductions as well as the phosphorylation-dependent ubiquitin-proteasome system which mediates c-Rel activation and degradation of Myc and p53 [43, 55]. The gene discussed is REL; the disease is diffuse large B-cell lymphoma.