Conversely, in ABC-DLBCL, TP53 mutations were associated with significantly upregulated REL mRNA (Supplementary Fig. S5B) and higher nuclear c-Rel protein levels (Fig. 4C), and p63+ ABC-DLBCL had trend for elevated nuclear c-Rel protein levels (P = 0.06, Fig. 4D). The gene discussed is REL; the disease is diffuse large B-cell lymphoma.