CD40 and diffuse large B-cell lymphoma: Although c-Rel nuclear expression did not show distinctive GEP signature in the overall ABC-DLBCL, within the p65+ ABC-DLBCL subset there were 64 DEGs between c-Rel+ and c-Rel− (FDR < 0.25), and within the p50+ ABC-DLBCL subset 28 DEGs (FDR < 0.30) (Supplementary Fig. S2O-2P; Supplementary Table S3), supporting the idea that c-Rel function depended on p65 and p50 activation as suggested by the survival analysis (Fig. 2E-2F).