In c-Rel+/p65+ (versus c-Rel−/p65+) ABC-DLBCL, SIGIRR which attenuates the TLR4 signaling, AEBP1, TFE3 (which activates CD40L expression), and HSPB1 (encoding Hsp27 which can either decrease IKK2 activity [50], or enhance proteasomal degradation of IκBα [51]), were upregulated; SETD6, encoding a methyltransferase which impedes p65 function, was downregulated. The gene discussed is SETD6; the disease is diffuse large B-cell lymphoma.