This was suggested by the upregulation of FOXP3 (Fig. 3F-3G) in c-Rel+ DLBCL which was opposite to the decrease of Myc in c-Rel+ DLBCL (≥5% and 30% cutoff respectively) (Fig. 3B-3C), and upregulation of FBXW7 (Fig. 3H), PIN1 (P < 0.0001), and PPP2R2A (P = 0.043) (which facilitate Myc degradation [43]) in c-Rel+ GCB-DLBCL. This evidence concerns the gene FBXW7 and diffuse large B-cell lymphoma.