In order to identify the dependency and distinctive functions of c-Rel versus other NF-κB subunits, we compared the GEP of c-Rel+ and c-Rel− within p50−, p65−, p52−, RelB−, p50+, p65+ p52+ and RelB+ DLBCL subsets individually. This evidence concerns the gene CD40 and diffuse large B-cell lymphoma.