REL and diffuse large B-cell lymphoma: In p63− DLBCL, c-Rel expression was associated with upregulation of BCL6, EGR1, AEBP1, C7orf68, CCNG2, CCNI, ILKAP, and PSMG4 (encoding a chaperone protein which promotes assembly of the 20S proteasome) and downregulation of FBXO22 (involved in degradation of specific proteins in response to p53 induction) (Fig. 3L).