Furthermore, we examined the effect of JTE-013 or CAY-10444 on fibrosis markers, including α-smooth muscle actin (α-SMA), procollagen α1(I) (Col α1(I)), procollagen α1(III) (Col α1(III)) and TGF-β1 in BDL-induced mouse liver fibrosis. The gene discussed is ACTA1; the disease is Hepatic fibrosis.