STAT3 and viral infectious disease: CEAS revealed enriched motifs for STAT5, STAT6 and c-Myb in the target promoters (Table 1), but also for novel transcription factors involved in stress response (i.e. HSF, HSF1, HSF2 and ATF), viral infection (i.e. STAT1 and STAT3), cell proliferation (i.e. MEIS1/AHOXA9, E2F, E2F1, STAT3, PAX2/3/8 and SPI1) and metabolic regulation (i.e. p300 and CREB) with P-values below 10−5 (Table 1).