PLEK and atherosclerosis: Our second most significant association, rs6713972, located in pleckstrin homology domain containing family B member 2 (PLEKHB2), is in the same family as PHLDB1. Deficiency in another member of the pleckstrin homology containing gene family, pleckstrin homology-like domain, family A, member 1 (PHLDA1) has been shown to be protective against atherosclerosis through regulation of cholesterol efflux, apoptosis, and peroxiredoxin-1 expression in mice[60].