The changes of disorder probability between the wild type sequences (BRAF and JAK2) and those with the cancer driver SNPs (V600E and V617F, respectively) have been predicted by five different methods which include highly ranked methods in CASP10 (Monastyrskyy et al., 2014) such as DISOPRED3, PrDOS, Biomine_MFDp and a recent method using backbone dynamics, DynaMine (Cilia et al., 2014) (Figures S2, S4). This evidence concerns the gene BRAF and cancer.