In order to identify miRNA potentially involved in tumoral progression toward aggressive and malignant phenotype, we used the following criteria: (1) miRNA targets (predicted by databases and already published targets) should be linked to the “aggressive pathway”; (2) targets mRNA expression should be inversely correlated to miRNA expression at mRNA level; (3) significant correlation should be observed between miRNA expression and the main molecular markers of cell cycle taking into account in the tumor grading (i.e., Ki-67 and p53). The gene discussed is TP53; the disease is neoplasm.