Inactivating mutations in SWI/SNF family member genes (ARID1A, ARID1B, ARID2, and SMARCA4) and in members of another chromatin-remodeling family referred to as the poly comb complex (EZH2, BMI1, and JARID1B/KDM5B) have been found altered in melanoma (107, 151–153). Here, EZH2 is linked to melanoma.