AURKC and male infertility: Recently, three naturally occurring mutations in the human Aurora-C kinase gene were reported to be associated with male infertility: c.144delC, which deletes a cytosine in exon 3 (8); c.686G > A, which is a missense mutation in exon 6 (p.Cys229Tyr) (55); and c.436-2A.G, which is a splicing site mutation that leads to the skipping of exon 5 (56).