CDA and disease arising from reactivation of latent virus: EBNA2 is important for B cell transformation when EBV establishes its latent infection and is the transactivator of various genes, including LMP1 that activates NF-κB (Longnecker et al. 2013); thus, it is related to antibody production and the expression of activation-induced cytidine deaminase (Tran et al. 2010).