ACE and Stroke: Better management of pre-stroke risk factors, particularly the use of ACE inhibitors (Selim et al. 2005; Álvarez-Sabín et al. 2007), aspirin (Wilterdink et al. 2001; Ovbiagele et al. 2008) and the wider use of pre-stroke statins (Yoon et al. 2004) may prevent catastrophic stroke that is common in the African setting (Feigin et al. 2009).