Corresponding with the ethanol-associated motor impairments, cerebellar atrophy, cell loss in Purkinje and granule cell cortical layers, and irregular structure of the subcortical white matter, Hu, MAG-1, and ChAT mRNA levels were significantly reduced in the ethanol-exposed cerebella (Figures 3A, 3B, 3F). The gene discussed is CHAT; the disease is Cerebellar atrophy.