Masson’s trichome staining showed a massive leak of red blood cells from blood vessels into the tumor tissue of the Vdac1−/− RAS MEF (Fig. 6f) and more hemoglobine in the tumor (Additional file 15: Figure S11D), suggesting that the leak came from partial vascular remodeling, probably coupled with enhanced permeability. This evidence concerns the gene VDAC1 and neoplasm.