For these two groups, rs227731 (17q22), rs8610209 (IRF6), and rs2514527 (GDF6) were selected as risk predictors for cleft palate-soft only, whereas rs2073485 (IRF6), rs17389541 (IRF6), and rs1530300 (8q24) jointly contributed to the risk of cleft palate-hard. Here, GDF6 is linked to cleft palate.