We and others have identified four non-coding transcripts with abnormal expression in response to Fragile X repeat expansions at the FMR1 locus (Ladd et al., 2007; Khalil et al., 2008; Pastori et al., 2014), but their role in FXS/FXTAS/FXPOI phenotypes remains to be determined. Here, FMR1 is linked to fragile X syndrome.