However, vaccination of a small number of ovarian cancer patients with a peptide from the germ cell protein NY-ESO-1 was shown to induce low-avidity CD4+ T cell clonotypes that were insensitive to Treg cell-mediated suppression, suggesting that Treg cells act mostly against high-avidity CD4+ T cell clonotypes (45). The gene discussed is CD4; the disease is ovarian carcinoma.