It has to be noted that the total CD4+ cells did not change much during the course of infection while CD8+ T cells increased significantly by day 56 (Mean percent ± SE–CD4+ LCMV–day 14–32.7 ± 2.4; day 28–44.0 ± 3.1; day 56–41.7 ± 2.7; CD8+ LCMV–day 14–17.2 ± 1.6; day 28–22.2 ± 4.8, day 56–28.9 ± 3.9, day 14 vs. day 56 *p < 0.01), and METH did not modulate the CD4+ or CD8+ expression at later time points as well (data not shown). This evidence concerns the gene CD4 and infection.