Both noradrenaline and isoprenaline promote amyloid β peptide uptake and degradation by murine microglial cells through activation of β2-AR, thus providing a potential link between central noradrenergic neurotransmission and neuroinflammatory mechanisms in Alzheimer's disease (Kong et al., 2010). Here, ADRB2 is linked to early-onset autosomal dominant Alzheimer disease.