As a consequence, the use of β2-AR agonists has been suggested to be possibly beneficial in the treatment of sepsis through inhibiting LPS-elicited IL-18 (Mizuno et al., 2005), while recently the β2-AR antagonist propranolol has been shown to reduce circulating immunosuppressive M2b monocytes in severely burned children, suggesting a role for this drug in severely burned patients to reduce their susceptibility to opportunistic infections (Kobayashi et al., 2011). The gene discussed is ADRB2; the disease is Sepsis.