PI3Kγ indeed cooperates with GPCR kinase-2 [GRK-2, also known as β-adrenergic receptor kinase-1 (β-ARK-1)], a key biomarker molecule upregulated in human heart failure, that by mediating receptor tail phosphorylation and the following binding by β-arrestin, interrupts G-protein coupling and initiates the process of internalization (Woodall et al., 2014). This evidence concerns the gene GRK2 and heart failure.