BACE1 and early-onset autosomal dominant Alzheimer disease: Thus, BACE1 seems to play an important role in neuronal excitability and is essential for cognitive, emotional, and synaptic functions (Laird et al., 2005) and BACE1 inhibitors may normalize membrane excitability in Alzheimer’s disease patients with elevated BACE1 activity (Kim et al., 2007).