Acid-sensing cation channels (ASIC) have been extensively studied both in physiological and in pathological conditions for their wide distribution in the nervous system and since they represent key targets in many different aspects of acidosis, a condition that occurs during ischemic stroke, as previously analyzed (Waldmann et al., 1997; Wemmie et al., 2006). The gene discussed is ASIC1; the disease is ischemic stroke.