Brain preconditioning as an adaptive response to stroke requires in particular new protein transcription and translation; giving that HIF-1–dependent transcription is being clearly common in activating pathways of several exchangers/transporters/ionic channels involved in stroke, scientific community has assigned a key role to HIF-1α, as a master transcriptional regulator of cellular and developmental response to hypoxia. This evidence concerns the gene HIF1A and stroke disorder.