In logistic regression analysis, critical limb ischemia (odds ratio [OR] 4.59, 95% CI 2.76-7.63; P < 0.001), anemia (OR 2.15, 95% CI 1.14-4.05; P = 0.017), and hypertension (OR 3.44, 95% CI 1.48-7.97; P = 0.004) were significantly associated with elevated CRP values, while age (OR 1.09, 95% CI 1.07-1.13; P < 0.001) was associated with impaired renal function. The gene discussed is CRP; the disease is Hypertension.