In the univariable analysis older age (P < 0.001), critical limb ischemia (P = 0.012), anemia (P = 0.018), history of cardiovascular disease (P = 0.002), decreased eGFR (P < 0.001), and higher CRP values (P = 0.009) were significantly associated with MACE (Table 2). This evidence concerns the gene CRP and anemia (phenotype).