Transgenic over-expression of cortocotropin releasing hormone (Crh) in mice has also generated a model of Cushing's disease (Stenzel-Poore et al., 1992), and an ENU induced mouse mutant with a Crh promoter mutation has been reported to develop Cushing's Syndrome (Bentley et al., 2014). Here, CRH is linked to Cushing syndrome due to macronodular adrenal hyperplasia.