The phenotypic features of Aip+/− mice are similar to that observed in FIPA patients, who have AIP mutations and predominately develop GH secreting adenomas, although some patients may also develop PRL or ACTH secreting and non-functioning adenomas (Leontiou et al., 2008, Vierimaa et al., 2006, Raitila et al., 2010). This evidence concerns the gene GH1 and adenoma.