APC and colorectal cancer: We have previously shown that truncating APC mutations found in human colorectal cancers (e.g., APC1–1450; expressing the first 1450 amino acids) dominantly inhibit microtubule dynamics by forming a hetero-oligmoer with full length APC that inhibits the activity of the microtubule plus-end binding protein EB1 [19, 22, 23, 28].