CCL8 mRNA expression was detected in the lung metastases of the metastatic system (newborn model) and in circulating tumor cells of the non-metastatic system (adult model) (Figure 7) We could not prove the presence of CCL8 mRNA in cell culture derived from the primary tumor, although by analyzing the whole subcutaneous tumor tissue CCL8 was detectable by immunohistochemistry in a small group of tumor cells (Figure 7C). The gene discussed is CCL8; the disease is neoplasm.