As reported by others, miR-329 blocks the G1/S transition in LN18, dramatically suppresses cell proliferation and decreases colony formation [41]; miR-424 and miR-381 synergistically suppress the proliferation and survival of renal cancer cells [42]; and miR-655 up-regulation inhibits esophageal squamous cell carcinoma cell invasiveness by targeting PTTG1 [43]. The gene discussed is PTTG1; the disease is esophageal squamous cell carcinoma.